NECESSITY Project originates from the realization that clinical trial design in complex diseases such as Sjögren’s disease requires a personalised/stratified medicine approach alongside tailored outcome measures which are able to monitor systemic changes, functional readouts and patient perception.
NECESSITY Project aims to identify and validate new clinical end-points for Sjögren’s disease with the ambition to provide tailored outcome measures for use in future clinical trials (Objective 1).
NECESSITY Project aims to discover and validate discriminative biomarkers for stratification of Sjögren’s disease patients (Objective 2).
Finally, these new clinical end-points and biomarkers will be validated in an original multi-arms multi-stages clinical trial (Objective 3).
